大自然为什么选择磷主导生命

磷酸单酯和双酯被漫长的进化过程选择为生命体的核心.磷酸酯功能的多样性需要磷酰基转移酶不断地进化来实现.现今磷酰基转移酶的催化机制已经得到了广泛研究.通过高分辨X射线晶体衍射技术(X-ray)与19FNMR的联用,来研究磷酰基转移酶的金属氟化物过渡态类似物,可以从原子层面上阐述磷酰基转移的机理.该催化机理充分地解释了磷酸酯的一对相互"矛盾"的性质,即磷酸酯结构的极其稳定性与磷酰基在信号传导过程中的灵活可调性.通过对元素周期表中其他元素的含氧酸根及其酯的性质的研究,目前还无法找出一个更加合适的元素来替代磷的这些重要功能,因而这些证据都支持了Todd的说法:"哪里有生命,哪里就一定有磷".     

An energy-based microstructure model to account for fatigue scatter in polycrystals

Scatter observed in the fatigue response of a nickel-based superalloy, U720, is linked to the variability in the microstructure. Our approach is to model the energy of a persistent slip band (PSB) structure and use its stability with respect to dislocation motion as our failure criterion for fatigue crack initiation. The components that contribute to the energy of the PSB are identified, namely, the stress field resulting from the applied external forces, dislocation pile-ups, and work-hardening of the material is calculated at the continuum scale. Further, energies for dislocations creating slip in the matrix/precipitates, interacting with the GBs, and nucleating/agglomerating within the PSB are computed via molecular dynamics simulations. Through this methodology, fatigue life is predicted based on the energy of the PSB, which inherently accounts for the microstructure of the material. The present approach circumvents the introduction of uncertainty principles in material properties. It builds a framework based on mechanics of microstructure, and from this framework, we construct simulated microstructures based on the measured distributions of grain size, orientation, neighbor information, and grain boundary character, which allows us to calculate fatigue scatter using a deterministic approach. The uniqueness of the approach is that it avoids the large number of parameters prevalent in previous fatigue models. The predicted lives are in excellent agreement with the experimental data validating the model capabilities.     

Percentile residual life orders

In this paper we study a family of stochastic orders of random variables defined via the comparison of their percentile residual life functions. Some interpretations of these stochastic orders are given, and various properties of them are derived. The relationships to other stochastic orders are also studied. Finally, some applications in reliability theory and finance are described. Copyright © 2010 John Wiley & Sons, Ltd.     

具有剩余寿命且排队空间有限的M/G/1排队模型非负解的存在唯一性

研究了以剩余寿命作为增补变量,排队空间有限的M/G/1排队模型,利用泛函分析中线性算子半群的积分半群理论讨论了该模型的瞬态解的存在唯一性问题。     

少子寿命和表面形貌与多孔硅发光性能的关系

研究了不同时间腐蚀的多孔硅的光致发光性能与多孔硅的表面形貌和少子寿命之间的关系。结果表明,多孔硅的发光来自与氧空位有关的缺陷,而多孔硅表面的氢原子能够钝化多孔硅表面的非辐射中心从而提高多孔硅的发光效率。多孔硅的空隙度随腐蚀时间的延长而增大,这也导致了多孔硅的少子寿命的降低,从而造成多孔硅的光致发光效率随多孔硅空隙度的增大以及少子寿命的降低而提高。另外,原子力显微照片表明长时间的腐蚀使多孔硅表面层被化学腐蚀,从而降低了多孔硅表面的粗糙度。     

单分子荧光检测在生命科学中的应用

文章对单分子荧光检测在分子马达、离子通道、信号分子、蛋白折叠、蛋白构象变化动力学、酶活性反应、细胞过程实时观察等生命科学领域中的应用进行了介绍.这些研究结果表明,单分子荧光检测在研究生物大分子的活动规律与机制方面不但有着无法替代的优越性,而且有着广阔的发展空间.     

CE模型下指数分布步加试验的贝叶斯估计

本文利用Gibbs抽样法得到了CE模型下指数分布场合步进应力加速寿命试验的多层Bayes参数估计,最后通过模拟比较表明多层Bayes估计比最大似然估计更加有效而实用。     

Modelling and forecasting mortality in Spain

Experience shows that static life tables overestimate death probabilities. As a consequence of this overestimation the premiums for annuities, pensions and life insurance are not what they actually should be, with negative effects for insurance companies or policy-holders. The reason for this overestimation is that static life tables, through being computed for a specific period of time, cannot take into account the decreasing mortality trend over time. Dynamic life tables overcome this problem by incorporating the influence of the calendar when graduating mortality. Recent papers on the topic look for the development of new methods to deal with this dynamism.     

Notch fatigue of Cu_(50)Zr_(50) metallic glasses under cyclic loading: molecular dynamics simulations

Molecular dynamics simulation is performed to simulate the tension–compression fatigue of notched metallic glasses(MGs), and the notch effect of MGs is explored. The notches will accelerate the accumulation of shear transition zones, leading to faster shear banding around the notches' root causing it to undergo severe plastic deformation. Furthermore, a qualitative investigation of the notched MGs demonstrates that fatigue life gradually becomes shorter with the increase in sharpness until it reaches a critical scale. The fatigue performance of blunt notches is stronger than that of sharp notches. Making the notches blunter can improve the fatigue life of MGs.     

Environmentally benign green composites based on epoxy resin/bacterial cellulose reinforced glass fiber: Fabrication and mechanical characteristics

Bio-based bacterial cellulose (BC) epoxy composites were manufactured and their mechanical properties were examined. The BC was initially fabricated from Vietnamese nata de coco by means of alkaline pretreatment followed by solvent exchange. The obtained fibers were dispersed in epoxy resin (EP) by both mechanical stirring and ultrasonic techniques. The resulting blend was used as the matrix for glass-fiber (GF) composite fabrication using a prepreg method followed by multiple hot-press-curing steps. The morphology, mechanical characteristics and mode-I interlaminar fracture toughness of the fabricated composites were investigated. With a 0.3-wt% BC content, the mode-I interlaminar fracture toughness for both crack initiation and crack propagation were improved by 128.8% and 1110%, respectively. The fatigue life was dramatically extended by a factor of 12, relative to the unmodified composite. Scanning electron microscopy images revealed that the BC plays a vital role in increasing the interlaminar fracture toughness of a GF/EP composite via the mechanisms of crack reflection, debonding and fiber-bridging.